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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB3
All Species:
6.67
Human Site:
S517
Identified Species:
13.33
UniProt:
Q16875
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16875
NP_001138915.1
520
59609
S517
S
R
S
S
A
D
S
S
R
K
H
_
_
_
_
Chimpanzee
Pan troglodytes
XP_001147864
523
59913
G517
Q
A
C
L
N
W
K
G
V
M
R
N
A
A
_
Rhesus Macaque
Macaca mulatta
XP_001107535
520
59589
S517
S
R
S
S
A
D
S
S
R
K
H
_
_
_
_
Dog
Lupus familis
XP_544267
559
63551
S530
S
F
E
E
H
V
A
S
T
S
A
A
L
P
N
Cat
Felis silvestris
Mouse
Mus musculus
P70265
519
59907
I516
Q
P
K
T
Q
V
S
I
P
V
V
_
_
_
_
Rat
Rattus norvegicus
O35552
555
63657
A517
E
H
V
A
S
T
S
A
A
L
P
S
C
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516067
579
65588
K576
A
G
Q
P
L
L
G
K
A
C
L
_
_
_
_
Chicken
Gallus gallus
Q91348
470
54386
Frog
Xenopus laevis
NP_001088535
470
54750
Zebra Danio
Brachydanio rerio
NP_998562
536
62010
S520
L
S
E
A
C
L
R
S
F
L
H
Y
L
Q
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.7
99.6
84.6
N.A.
65.5
89.9
N.A.
76.6
61.1
65.5
72.3
N.A.
N.A.
N.A.
47.1
N.A.
Protein Similarity:
100
97.1
99.8
87.6
N.A.
77.8
91.7
N.A.
84.2
77.1
76.7
84.1
N.A.
N.A.
N.A.
62.8
N.A.
P-Site Identity:
100
0
100
13.3
N.A.
9
6.6
N.A.
0
0
0
13.3
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
0
100
20
N.A.
18.1
26.6
N.A.
9
0
0
26.6
N.A.
N.A.
N.A.
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
40.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
59.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
17
17
0
9
9
17
0
9
9
9
9
0
% A
% Cys:
0
0
9
0
9
0
0
0
0
9
0
0
9
0
0
% C
% Asp:
0
0
0
0
0
17
0
0
0
0
0
0
0
0
0
% D
% Glu:
9
0
17
9
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
9
0
0
0
0
0
0
9
0
0
0
0
0
0
% F
% Gly:
0
9
0
0
0
0
9
9
0
0
0
0
0
0
0
% G
% His:
0
9
0
0
9
0
0
0
0
0
25
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% I
% Lys:
0
0
9
0
0
0
9
9
0
17
0
0
0
0
0
% K
% Leu:
9
0
0
9
9
17
0
0
0
17
9
0
17
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% M
% Asn:
0
0
0
0
9
0
0
0
0
0
0
9
0
0
9
% N
% Pro:
0
9
0
9
0
0
0
0
9
0
9
0
0
9
9
% P
% Gln:
17
0
9
0
9
0
0
0
0
0
0
0
0
9
0
% Q
% Arg:
0
17
0
0
0
0
9
0
17
0
9
0
0
0
0
% R
% Ser:
25
9
17
17
9
0
34
34
0
9
0
9
0
0
0
% S
% Thr:
0
0
0
9
0
9
0
0
9
0
0
0
0
0
0
% T
% Val:
0
0
9
0
0
17
0
0
9
9
9
0
0
0
9
% V
% Trp:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
34
34
34
42
% _